<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!uFqc!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!uFqc!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 424w, https://substackcdn.com/image/fetch/$s_!uFqc!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 848w, https://substackcdn.com/image/fetch/$s_!uFqc!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 1272w, https://substackcdn.com/image/fetch/$s_!uFqc!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!uFqc!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png" width="1456" height="819" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:819,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:128407,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/186464050?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!uFqc!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 424w, https://substackcdn.com/image/fetch/$s_!uFqc!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 848w, https://substackcdn.com/image/fetch/$s_!uFqc!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 1272w, https://substackcdn.com/image/fetch/$s_!uFqc!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F394631f9-862a-4e5f-b5de-36439971b9f0_1920x1080.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p>LEAD is proud to share that we&#8217;ve doubled down on our investment in <a href="https://lotus.ai/">Lotus Health AI</a>, doubling down in the company&#8217;s <a href="https://techcrunch.com/2026/02/03/lotus-health-nabs-35m-for-ai-doctor-that-sees-patients-for-free/">$35M Series A fundraise</a> alongside Kleiner Perkins and CRV, following our initial investment in its Seed round in 2024. We couldn&#8217;t be more excited to see all the progress that Lotus has made in building the AI doctor powered by real doctors.</p><p>In 2024, when we first met Lotus&#8217;s founder, <a href="https://www.linkedin.com/in/kjdhaliwal/">KJ Dhaliwal</a>, he posed a compelling question: What if siloed health records, wearable data, insurance information, millions of peer-reviewed studies, and clinical guidelines were unified in one app?</p><p>As the business continued to mature over the next two years, that insight evolved into a bolder vision: making world-class primary care accessible to every American, 24/7. After years of development, Lotus is making this vision real. Partnering with clinicians from Harvard, UCSF, Stanford, Johns Hopkins, and other leading institutions, Lotus delivers personalized primary care powered by real doctors, unifying fragmented health data with insurance information and evidence-based medicine, available to patients <em>for free</em>.</p><blockquote><p>&#8220;Industry-changing companies are rarely built by insiders&#8212;they know too much to question the system. KJ brings an outsider imagination with his technical experience of scaling and exiting one of South Asia&#8217;s most successful consumer apps. He&#8217;s assembled an exceptional team to ensure this product reaches the people who need it most.&#8221; - <em>Justin Driscoll, Principal at LEAD</em></p></blockquote><h4><strong>Healthcare is Broken. Primary Care Is Worse.</strong></h4><p>When people discuss the state of U.S. healthcare, many point out that we spend <a href="https://www.healthsystemtracker.org/chart-collection/u-s-life-expectancy-compare-countries/#Life%20expectancy%20and%20per%20capita%20healthcare%20spending%20(PPP%20adjusted),%202023">twice as much</a> per capita as other large, wealthy countries yet still deliver<a href="https://www.healthsystemtracker.org/chart-collection/u-s-life-expectancy-compare-countries/#Life%20expectancy%20and%20per%20capita%20healthcare%20spending%20(PPP%20adjusted),%202023"> worse</a> health outcomes. However, as problematic as our overall health system is, the primary care system is even worse.</p><p><em><strong>Acute Physician Shortage:</strong></em><strong> </strong>In 2022, <a href="https://physiciansfoundation.org/new-report-u-s-primary-care-system-crumbling-amid-historic-disinvestment-and-surge-in-chronic-diseases/">30%</a><strong> </strong>of U.S. adults lacked a consistent source of care, the highest level in a decade, even with historically high rates of insurance coverage. Despite primary care&#8217;s vital role in providing <a href="https://www.graham-center.org/content/dam/rgc/documents/publications-reports/reports/PrimaryCareChartbook2021.pdf">first contact, coordination, continuity, and comprehensiveness of care</a>, primary care physicians account for only about <a href="https://www.graham-center.org/content/dam/rgc/documents/publications-reports/reports/PrimaryCareChartbook2021.pdf">one-third</a><strong> </strong>of the physician workforce, well below the Council of Graduate Medical Education&#8217;s recommended 40%. Factors such as retirements and fewer medical graduates choosing family medicine for more lucrative fields are only widening the gap.</p><p><em><strong>Fragmentation and Care Gaps:</strong></em><strong> </strong>At the same time, driven by similar forces, the U.S. healthcare system has become increasingly fragmented and specialized in its care delivery, even as the patient population has shifted toward chronic disease management that requires coordinated, continuous care. Today, <a href="https://www.cdc.gov/pcd/issues/2025/24_0539.htm">76.4%</a> of U.S. adults live with at least one chronic condition, and <a href="https://www.cdc.gov/pcd/issues/2025/24_0539.htm">51.4%</a> suffer from multiple conditions. These patients bear the brunt of care fragmentation, as managing chronic diseases requires sustained care coordination over long periods.</p><h4><strong>How We Broke Primary Care (And Why It Matters)</strong></h4><p>The problem of U.S. primary care is multifaceted.</p><p><em><strong>Misaligned Payment Incentives: </strong></em>The still-dominant fee-for-service model disincentivizes primary care under the American Medical Association&#8217;s Relative Value Scale, and the Relative Value Units assigned to primary care services are <a href="https://health.ucdavis.edu/media-resources/family-medicine/documents/pdf/Rev-PC-Recommendations-and-Proceedings-2025.pdf">much lower</a> than those for subspecialties, contributing to lower salaries for family physicians, general internists, and pediatricians.</p><p><em><strong>Declining Payor Investments: </strong></em>Additionally, insurers&#8217; investments in primary care as a share of total healthcare spending fell from <a href="https://www.milbank.org/publications/the-health-of-us-primary-care-2024-scorecard-report-no-one-can-see-you-now/">5.4%</a> in 2012 to <a href="https://www.milbank.org/publications/the-health-of-us-primary-care-2024-scorecard-report-no-one-can-see-you-now/">4.7%</a> in 2021, despite primary care accounting for<a href="https://www.nationalacademies.org/read/25983/chapter/3"> 35%</a> of healthcare visits.</p><p><em><strong>The Net Impact Of It All: </strong></em>These forces have resulted in a sharp rise in the number of Americans who lack a consistent source of healthcare, with medically underserved individuals most affected. Even for those with access to primary care, many physicians are <em>overburdened </em>and<em> under-resourced</em>, resulting in limited patient access, short visits, and many patients <a href="https://health.ucdavis.edu/media-resources/family-medicine/documents/pdf/Rev-PC-Recommendations-and-Proceedings-2025.pdf">dissatisfied</a> with timeliness and quality of care.</p><h4><strong>A Category Ripe for Disruption</strong></h4><p>As a health specialist investor, LEAD has had our eyes on the health data space ever since the publication of The Trusted Exchange Framework and Common Agreement (TEFCA) in early 2022, which created the framework for a nationwide &#8220;network-of-networks&#8221; to enable secure, standardized health data sharing for healthcare stakeholders. However, finding the right opportunity took some time.</p><blockquote><p><em>&#8220;Before investing in Lotus, we met with hundreds of startups in the space and struggled to find a consumer platform that offered both unified health insights and intervention capabilities within the healthcare system.&#8221;</em></p><p><em>Kaiwen Liu, Associate at LEAD</em></p></blockquote><p>Since our Seed investment in May 2024, we&#8217;ve grown increasingly excited as the team transforms vision into product - though until now, we&#8217;ve kept that excitement to ourselves while the company built in stealth.</p><p>The landscape has shifted dramatically even in the months since our initial investment in 2024. Major technology companies entering healthcare signal that the market recognizes what we saw early: AI-powered care delivery is not theoretical but inevitable. This influx of attention and capital is expanding the category and accelerating user adoption. More than 5% of all ChatGPT messages globally are about health care, and more than <a href="https://www.axios.com/2026/01/05/chatgpt-openai-health-insurance-aca">40 million</a> people globally turn to ChatGPT daily for health information.</p><p>For purpose-built healthcare companies with clinical rigor and consumer trust, this rising tide creates opportunity rather than competition.</p><h4><strong>Closing Thoughts</strong></h4><p>We invested in Lotus and the team because millions of Americans urgently need better primary care solutions. We believe Lotus has the potential to help fill the gap and deliver high-quality, continuous, whole-person care for people suffering from chronic conditions, while supporting under-resourced primary care physicians.</p><p>This can truly transform health outcomes for millions, if not billions of people. We couldn&#8217;t be more excited to support Lotus in its next chapter.</p><div id="youtube2-v12NCH9DAuQ" class="youtube-wrap" data-attrs="{&quot;videoId&quot;:&quot;v12NCH9DAuQ&quot;,&quot;startTime&quot;:null,&quot;endTime&quot;:null}" data-component-name="Youtube2ToDOM"><div class="youtube-inner"><iframe src="https://www.youtube-nocookie.com/embed/v12NCH9DAuQ?rel=0&amp;autoplay=0&amp;showinfo=0&amp;enablejsapi=0" frameborder="0" loading="lazy" gesture="media" allow="autoplay; fullscreen" allowautoplay="true" allowfullscreen="true" width="728" height="409"></iframe></div></div>

Giving Every American World-Class Primary Care, for Free.

Why We Invested in 2024 (and Doubling Down) in Lotus Health AI

Sports fans are patients & patients are sports fans.

Why Does Every Health System Want a Sports Jersey on Its Wall?

<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!7koX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" width="1456" height="968" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:968,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:6605001,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p>When the topic of chronic diseases is discussed in the United States, an increasing amount of attention has been directed, and rightfully so, toward clean ingredients in our food supply and getting adequate exercise. However, not many people consider or monitor the quality of the physical spaces that hold our presence - environments where we live, work, and sleep.</p><p>As my mentor would say, &#8220;You cannot heal in the same environment where you got sick.&#8221;</p><p>Just like food, your home is medicine too.</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Thanks for reading! Subscribe now to receive LEAD&#8217;s latest posts.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><p><strong>The Overlooked Factor: Where We Spend 90% of Our Lives</strong></p><p>We spend <a href="https://www.epa.gov/indoor-air-quality-iaq/improving-your-indoor-environment">90%</a> of our time indoors, and the current medical literature recognizes that <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4841276/">70% to 90%</a> of disease risks may be <a href="https://www.sciencedirect.com/science/article/pii/S2666979X24001757">due</a> to environmental differences.</p><p>A health-conscious individual could get 100+ blood tests every 6 months and keep adding to the supplement stack, but if the underlying environmental factors contributing to the symptoms, such as chronic mold or PFAS exposure, are not addressed, at what point is the current wellness industry (a <a href="https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/the-trends-defining-the-1-point-8-trillion-dollar-global-wellness-market-in-2024">$1.8T market</a>) simply putting band-aids over problems without ever addressing the underlying causes, all the while draining people&#8217;s wallets?</p><p><strong>The Unseen Disease-Causing Substances in Our Homes</strong></p><p>It is estimated that approximately <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10190119/">47%</a> of residential buildings show signs of mold, and that chronic indoor damp/mold-contaminated air exposure can <a href="https://pubmed.ncbi.nlm.nih.gov/32078193/">contribute</a> to low-grade pro-inflammatory responses and damage human airways. Evidence suggests that building dampness and mold are associated with a <a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0668.2007.00475.x">30-50%</a> increase in a variety of respiratory and asthma-related health outcomes.</p><p>And chronic mold exposure is just the tip of the iceberg.</p><p><strong>Flame Retardants</strong></p><p>Applied to prevent or slow the growth of fire, these chemicals are found in couches, mattresses, carpets, and building materials.</p><p>Flame retardants are <a href="https://pubmed.ncbi.nlm.nih.gov/21268442/">associated with adverse health effects</a> such as endocrine and thyroid disruption, immunotoxicity, reproductive toxicity, and cancer. </p><p><em>Imagine sleeping on these chemicals for approximately 1/3 of our lives.</em></p><p><strong>Phthalates</strong></p><p>Widely found in personal care products, scented products, and plastic coatings, phthalates are known <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8157593/">endocrine disruptors</a> and can have detrimental impacts on the human reproductive, neurological, and developmental systems.</p><p><strong>Volatile Organic Compounds</strong></p><p>VOCs are found in a wide range of everyday products and materials such as paints, adhesives, carpets, beauty products, and cleaning products. These chemicals cause oxidative stress, inflammation, and <a href="https://pubmed.ncbi.nlm.nih.gov/38320440/">elevated lung cancer risk</a>. </p><p>The level of VOCs can also be <a href="https://pubmed.ncbi.nlm.nih.gov/27163962/">higher</a> indoors than outdoors, with some compounds reaching levels <a href="https://www.epa.gov/indoor-air-quality-iaq/volatile-organic-compounds-impact-indoor-air-quality">two to five times</a> higher inside homes.</p><p><strong>PFAS (&#8221;Forever Chemicals&#8221;)</strong></p><p>Per- and polyfluroalkyl substances are <a href="https://ncpure.collaboratory.unc.edu/science/where-are-pfas-found/">everywhere</a>, from personal care products and food packagings, to non-stick cookwares and water-repellent chemicals used on upholstery. The USGS estimates that at least <a href="https://www.usgs.gov/news/national-news-release/tap-water-study-detects-pfas-forever-chemicals-across-us">45%</a> of tap water in the U.S. has one or more types of PFAS.</p><p>Studies have revealed associations between specific PFAS exposure with <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">negative health effects</a> such as altered immune and thyroid function, liver disease, insulin dysregulation, kidney disease, adverse reproductive outcomes, and cancer. What&#8217;s more concerning is that these substances <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">bind to proteins</a> and accumulate in the body.</p><p>PFAS can also <a href="https://www.sciencedirect.com/science/article/pii/S0160412024003581">permeate the skin barrier</a> and reach the body&#8217;s bloodstream, making dermal exposure another route of adding to the accumulated burden of PFAS.</p><p><strong>Man-made Electromagnetic Radiation (EMR)</strong></p><p>Man-made EMR, in contrast to natural EMR, are <a href="https://www.nature.com/articles/srep14914">polarized</a>, and the <a href="https://www.nature.com/articles/srep14914">health effects include</a> DNA and protein damage, which may result in cell death, reproductive declines, and cancer.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!CpuG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" width="1280" height="720" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:720,&quot;width&quot;:1280,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:230182,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p><strong>The Opportunity:</strong></p><p>From 2017-2023, more than <a href="https://www.census.gov/library/stories/2025/01/return-home-migration.html">40 million people</a> moved in the United States, and the average person in the U.S. can expect to relocate <a href="https://www.census.gov/topics/population/migration/guidance/calculating-migration-expectancy.html#:~:text=Using%202007%20ACS%20data%2C%20it%20is%20estimated,expected%20number%20of%20moves%20is%20only%202.7.)">11.7 times</a> in their lifetime.</p><p>What if every time someone moves, they could order a test kit to make sure that the new environment is supportive of health? What if in humid environments, people could check the health of their homes every six months?</p><p>What if one platform could test for:</p><ul><li><p>Lighting</p></li><li><p>EMF</p></li><li><p>Water quality</p></li><li><p>Air quality</p></li><li><p>Mold</p></li><li><p>Chemical hazards</p></li></ul><p>&#8230;and then instantly connect consumers with home specialists and solutions to address the issues found, rather than providing only pharmaceutical treatments or supplements?</p><p>If you are an innovator, builder, or passionate about solving these challenges, reach out to me on <a href="https://www.linkedin.com/in/kaiwenliu6/">LinkedIn</a> or connect with us at <a href="mailto:dealflow@lead.vc">dealflow@lead.vc</a>.</p><div class="captioned-button-wrap" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="CaptionedButtonToDOM"><div class="preamble"><p class="cta-caption">Thanks for reading! Feel free to share it!</p></div><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p></div>

The overlooked aspect of health and wellness.

Home as Medicine

Comics Is Exploding, and GlobalComix Is Building the Platform for It

Why We Invested in 2024 (and Doubling Down) in Lotus Health AI

Why We Invested in 2024 (and Doubling Down) in Lotus Health AI

sign up to our newsletter