<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!JAp9!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!JAp9!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 424w, https://substackcdn.com/image/fetch/$s_!JAp9!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 848w, https://substackcdn.com/image/fetch/$s_!JAp9!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 1272w, https://substackcdn.com/image/fetch/$s_!JAp9!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!JAp9!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png" width="920" height="612" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/48281447-a3ae-4326-ac35-a576a5234903_920x612.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:612,&quot;width&quot;:920,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:930699,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/171012564?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!JAp9!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 424w, https://substackcdn.com/image/fetch/$s_!JAp9!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 848w, https://substackcdn.com/image/fetch/$s_!JAp9!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 1272w, https://substackcdn.com/image/fetch/$s_!JAp9!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F48281447-a3ae-4326-ac35-a576a5234903_920x612.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><div class="pencraft pc-reset icon-container restack-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-refresh-cw"><path d="M3 12a9 9 0 0 1 9-9 9.75 9.75 0 0 1 6.74 2.74L21 8"></path><path d="M21 3v5h-5"></path><path d="M21 12a9 9 0 0 1-9 9 9.75 9.75 0 0 1-6.74-2.74L3 16"></path><path d="M8 16H3v5"></path></svg></div><div class="pencraft pc-reset icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></div></div></div></div></a></figure></div><h4><strong>Poor Sleep: An Under-Recognized and Neglected <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6473877/">Epidemic</a> </strong></h4><p>Good sleep is essential for human health and a good quality of life. Yet, in modern society, insufficient and poor sleep is a pervasive problem that often goes unnoticed and unaddressed.</p><p>Reduced sleep duration has been <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6473877/">linked</a> to <strong>7 of the 15</strong> leading causes of death in the United States, including <strong>cardiovascular disease, malignant neoplasm, cerebrovascular disease, accidents, diabetes, septicemia, and hypertension.</strong></p><p>Quality of sleep also matters. Sleep disruptions - whether caused by lifestyle or environmental factors - impact the continuity of sleep and have substantial short-term and long-term <a href="https://www.dovepress.com/article/download/32942">consequences</a>, even in otherwise healthy adults. Short-term consequences include <strong>increased stress responsivity, somatic pain, emotional distress, mood disorders, and performance deficits.</strong> The long-term consequences include, but are not limited to, <strong>colorectal cancer, metabolic syndrome, type 2 diabetes mellitus, and increased all-cause mortality in men.</strong></p><p>Beyond personal health, the societal toll is also staggering. <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC5627640/">One</a> study estimates that insufficient sleep alone costs the US economy up to <strong>$411 billion</strong> <strong>per year </strong>due to increased risk of sickness and dying, reduced work performance, and suboptimal school performance in children. </p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Subscribe to receive the latest LEAD posts.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><h4>A Market with Huge Demand and Unmet Needs</h4><p>People struggling with sleep go to enormous lengths to get a good night&#8217;s rest. In 2024, the global market for sleep aids was valued at <a href="https://www.globenewswire.com/news-release/2024/10/24/2968424/28124/en/Sleep-Aids-Market-Forecast-to-Cross-89-Billion-by-2030-Trends-and-Projections-by-Product-Sleep-Disorder-and-Distribution-Channel-at-a-Global-Regional-and-Country-Level.html">$64B</a> and is expected to grow to $89B by 2030.</p><p>Consumers are actively seeking solutions for better sleep, making the category the <strong><a href="https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/still-feeling-good-the-us-wellness-market-continues-to-boom">second-highest wellness priority</a></strong> after general health - taking precedence over nutrition, fitness, mindfulness, and appearance. In the pursuit of better rest, consumers are trying products such as earplugs, eye masks, weighted blankets, mouth tapes, nasal dilators, nasal strips, magnesium foot sprays, smart alarm clocks, and smart mattress systems, among others.</p><p>Yet, despite years of innovation and strong demand, many consumers still find current products and services insufficient to meet their sleep needs, making the sleep category one with the <strong><a href="https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/still-feeling-good-the-us-wellness-market-continues-to-boom">greatest unmet consumer need</a></strong>.</p><p>The caveat is that better sleep can often be achieved through consistent habits rather than more products. <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8511346/">Diet</a>, <a href="https://pubmed.ncbi.nlm.nih.gov/25596964/">exercise</a>, <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6751071/">exposure to natural daylight</a>, <a href="https://www.sciencedirect.com/science/article/abs/pii/S0048969722064026?via%3Dihub">bedroom darkness at night</a>, <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC6751071/">reduced screentime at night</a>, and <a href="https://www.sciencedirect.com/science/article/abs/pii/S0033062023000117?via%3Dihub">avoiding caffeine and alcohol later in the day</a> can all help improve sleep. </p><p>With that said, life circumstances - such as caring for a newborn, working night shifts, and frequent travel - can all disrupt good <a href="https://www.sciencedirect.com/science/article/abs/pii/S0033062023000117?via%3Dihub">sleep hygiene</a> and increase the demand for innovation to achieve better sleep.</p><h4><strong>Introducing Somnee - A Clinically Validated, Drug-Free Solution</strong></h4><p><a href="https://somneesleep.com/">Somnee</a> is a sleep headband that creates a proprietary brain mapping diagnosis with EEG sensors and provides non-invasive, gentle, and personalized electrical stimulation (tES). The product reduces sleep onset latency and increases both sleep duration and sleep efficiency.</p><p>Co-founded by <a href="https://www.sleepdiplomat.com/">Dr. Matt Walker</a>, <a href="https://scholar.google.com/citations?user=P3p-g5kAAAAJ&amp;hl=en">Dr. Ram Gurumoorthy</a>, <a href="https://scholar.google.com/citations?hl=en&amp;user=WYv36DIAAAAJ">Dr. Robert Knight</a>, <a href="https://scholar.google.com/citations?user=nicnuy4AAAAJ&amp;hl=en">Dr. Richard Ivry</a>, and led by <a href="https://www.linkedin.com/in/timrosa/">Tim Rosa</a>, Somnee is a clinically validated product shown to be more effective than melatonin in improving sleep efficiency and duration.</p><h4><strong>Joining Forces to Tackle the Epidemic </strong></h4><p>We invested in Somnee because it addresses a profoundly underserved market with serious health implications and is led by a world-class team delivering a clinically validated solution.</p><p>Addressing the epidemic of poor sleep requires innovation and collaboration. We are proud to partner with Somnee alongside Khosla Ventures, Marc Benioff&#8217;s TIME Ventures, the DeVos Family, Seaside Ventures, Nelstone Ventures, Metalab, and others, to advance effective sleep solutions and improve public health worldwide.</p><div class="captioned-button-wrap" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/why-we-invested-in-somnee?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="CaptionedButtonToDOM"><div class="preamble"><p class="cta-caption">Thanks for reading! Feel free to share this with anyone who might find it insightful.</p></div><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/why-we-invested-in-somnee?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://leadvc.substack.com/p/why-we-invested-in-somnee?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p></div><p></p>

Addressing the silent epidemic of poor sleep.

Why We Invested in Somnee

Comics Is Exploding, and GlobalComix Is Building the Platform for It

Why We Invested in GlobalComix

<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!7koX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" width="1456" height="968" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:968,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:6605001,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p>When the topic of chronic diseases is discussed in the United States, an increasing amount of attention has been directed, and rightfully so, toward clean ingredients in our food supply and getting adequate exercise. However, not many people consider or monitor the quality of the physical spaces that hold our presence - environments where we live, work, and sleep.</p><p>As my mentor would say, &#8220;You cannot heal in the same environment where you got sick.&#8221;</p><p>Just like food, your home is medicine too.</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Thanks for reading! Subscribe now to receive LEAD&#8217;s latest posts.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><p><strong>The Overlooked Factor: Where We Spend 90% of Our Lives</strong></p><p>We spend <a href="https://www.epa.gov/indoor-air-quality-iaq/improving-your-indoor-environment">90%</a> of our time indoors, and the current medical literature recognizes that <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4841276/">70% to 90%</a> of disease risks may be <a href="https://www.sciencedirect.com/science/article/pii/S2666979X24001757">due</a> to environmental differences.</p><p>A health-conscious individual could get 100+ blood tests every 6 months and keep adding to the supplement stack, but if the underlying environmental factors contributing to the symptoms, such as chronic mold or PFAS exposure, are not addressed, at what point is the current wellness industry (a <a href="https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/the-trends-defining-the-1-point-8-trillion-dollar-global-wellness-market-in-2024">$1.8T market</a>) simply putting band-aids over problems without ever addressing the underlying causes, all the while draining people&#8217;s wallets?</p><p><strong>The Unseen Disease-Causing Substances in Our Homes</strong></p><p>It is estimated that approximately <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10190119/">47%</a> of residential buildings show signs of mold, and that chronic indoor damp/mold-contaminated air exposure can <a href="https://pubmed.ncbi.nlm.nih.gov/32078193/">contribute</a> to low-grade pro-inflammatory responses and damage human airways. Evidence suggests that building dampness and mold are associated with a <a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0668.2007.00475.x">30-50%</a> increase in a variety of respiratory and asthma-related health outcomes.</p><p>And chronic mold exposure is just the tip of the iceberg.</p><p><strong>Flame Retardants</strong></p><p>Applied to prevent or slow the growth of fire, these chemicals are found in couches, mattresses, carpets, and building materials.</p><p>Flame retardants are <a href="https://pubmed.ncbi.nlm.nih.gov/21268442/">associated with adverse health effects</a> such as endocrine and thyroid disruption, immunotoxicity, reproductive toxicity, and cancer. </p><p><em>Imagine sleeping on these chemicals for approximately 1/3 of our lives.</em></p><p><strong>Phthalates</strong></p><p>Widely found in personal care products, scented products, and plastic coatings, phthalates are known <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8157593/">endocrine disruptors</a> and can have detrimental impacts on the human reproductive, neurological, and developmental systems.</p><p><strong>Volatile Organic Compounds</strong></p><p>VOCs are found in a wide range of everyday products and materials such as paints, adhesives, carpets, beauty products, and cleaning products. These chemicals cause oxidative stress, inflammation, and <a href="https://pubmed.ncbi.nlm.nih.gov/38320440/">elevated lung cancer risk</a>. </p><p>The level of VOCs can also be <a href="https://pubmed.ncbi.nlm.nih.gov/27163962/">higher</a> indoors than outdoors, with some compounds reaching levels <a href="https://www.epa.gov/indoor-air-quality-iaq/volatile-organic-compounds-impact-indoor-air-quality">two to five times</a> higher inside homes.</p><p><strong>PFAS (&#8221;Forever Chemicals&#8221;)</strong></p><p>Per- and polyfluroalkyl substances are <a href="https://ncpure.collaboratory.unc.edu/science/where-are-pfas-found/">everywhere</a>, from personal care products and food packagings, to non-stick cookwares and water-repellent chemicals used on upholstery. The USGS estimates that at least <a href="https://www.usgs.gov/news/national-news-release/tap-water-study-detects-pfas-forever-chemicals-across-us">45%</a> of tap water in the U.S. has one or more types of PFAS.</p><p>Studies have revealed associations between specific PFAS exposure with <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">negative health effects</a> such as altered immune and thyroid function, liver disease, insulin dysregulation, kidney disease, adverse reproductive outcomes, and cancer. What&#8217;s more concerning is that these substances <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">bind to proteins</a> and accumulate in the body.</p><p>PFAS can also <a href="https://www.sciencedirect.com/science/article/pii/S0160412024003581">permeate the skin barrier</a> and reach the body&#8217;s bloodstream, making dermal exposure another route of adding to the accumulated burden of PFAS.</p><p><strong>Man-made Electromagnetic Radiation (EMR)</strong></p><p>Man-made EMR, in contrast to natural EMR, are <a href="https://www.nature.com/articles/srep14914">polarized</a>, and the <a href="https://www.nature.com/articles/srep14914">health effects include</a> DNA and protein damage, which may result in cell death, reproductive declines, and cancer.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!CpuG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" width="1280" height="720" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:720,&quot;width&quot;:1280,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:230182,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p><strong>The Opportunity:</strong></p><p>From 2017-2023, more than <a href="https://www.census.gov/library/stories/2025/01/return-home-migration.html">40 million people</a> moved in the United States, and the average person in the U.S. can expect to relocate <a href="https://www.census.gov/topics/population/migration/guidance/calculating-migration-expectancy.html#:~:text=Using%202007%20ACS%20data%2C%20it%20is%20estimated,expected%20number%20of%20moves%20is%20only%202.7.)">11.7 times</a> in their lifetime.</p><p>What if every time someone moves, they could order a test kit to make sure that the new environment is supportive of health? What if in humid environments, people could check the health of their homes every six months?</p><p>What if one platform could test for:</p><ul><li><p>Lighting</p></li><li><p>EMF</p></li><li><p>Water quality</p></li><li><p>Air quality</p></li><li><p>Mold</p></li><li><p>Chemical hazards</p></li></ul><p>&#8230;and then instantly connect consumers with home specialists and solutions to address the issues found, rather than providing only pharmaceutical treatments or supplements?</p><p>If you are an innovator, builder, or passionate about solving these challenges, reach out to me on <a href="https://www.linkedin.com/in/kaiwenliu6/">LinkedIn</a> or connect with us at <a href="mailto:dealflow@lead.vc">dealflow@lead.vc</a>.</p><div class="captioned-button-wrap" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="CaptionedButtonToDOM"><div class="preamble"><p class="cta-caption">Thanks for reading! Feel free to share it!</p></div><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p></div>

The overlooked aspect of health and wellness.

Home as Medicine

<h3>What Is Throne?</h3><p>A passive, continuous health monitor embedded in your toilet seat turns a daily routine into valuable insights for gut health, hydration, and cancer detection. Throne is available today for stool and urine analysis and is designed as the &#8220;Whoop for Your Poop&#8221; for the 75 million Americans dealing with IBS, IBD, and prostate issues. The future version of Throne, known as the &#8220;Smoke Detector for Colon Cancer,&#8221; will expand its capabilities to include screening for one of the fastest-growing cancers in the United States.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!3IZ6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 424w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 848w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg" width="1200" height="630" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:630,&quot;width&quot;:1200,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:39385,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/208868655?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 424w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 848w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg aria-hidden="true" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><div><hr></div><p><span>Deciding to invest in a company usually hinges on two questions: 1) Will the founders find a way to succeed? 2) Is the target market large enough?</span></p><h3><span>Founder Bet</span></h3><p><a href="https://www.linkedin.com/in/scotthickle/"><span>Scott Hickle</span></a><span> is a founder who combines three qualities rarely found together: being a talent magnet, an obsession with solving the problem, and deep industry k</span><span data-color="#032b31" style="color: rgb(3, 43, 49);">nowledge. His motivation is straightforward &#8212; he&#8217;s passionate about saving lives and wants the Throne device on every accessible toilet. If you don&#8217;t believe us&#8230; His social handle is &#8220;</span><a href="https://x.com/ScottHickle"><span data-color="#032b31" style="color: rgb(3, 43, 49);">Poop Guy</span></a><span data-color="#032b31" style="color: rgb(3, 43, 49);">,&#8221; and he gave a </span><a href="https://www.youtube.com/watch?v=v42gznW6cuA"><span data-color="#032b31" style="color: rgb(3, 43, 49);">TED Talk </span></a><span data-color="#032b31" style="color: rgb(3, 43, 49);">on the history and significance of poop.</span></p><p><span data-color="#032b31" style="color: rgb(3, 43, 49);">Chasing an introduction to Throne kicked off an organic 18-month relationship before a check was written. We introduced him to multiple investo</span><span>rs who then joined this round, connected him with enterprise customers who remain engaged, and brought him before clinicians who initially questioned but ultimately left as believers in his right to win. Scott exemplifies a founder willing to bend reality with passionate intensity to make his business succeed.</span></p><p><span>His effectiveness is evident in the people he&#8217;s assembled. Scott recruited John Capodilupo, co-founder of Whoop and a key technical figure behind the $10B consumer health startup, who personally relates to the problem&#8212;living with ulcerative colitis. Scott also persuaded Ben Grynol, who previously led consumer growth at Levels, to join Throne. Scott established a medical advisory board with Dr. David Rubin and Dr. Mark Pimentel, renowned researchers with over 10,000 combined citations in IBS/IBD. Scott attracted an investor syndicate such as Emerson Collective, Will Ventures, Moxxie Ventures, Felix Capital, and Accomplice (an early supporter of Whoop).</span></p><h3><span>Market Bet</span></h3><p><span>In consumer health technology, continuous tracking now covers sleep, heart rate, glucose, and hormones, providing daily insights into bodily functions that influence habits. Despite valuable clinical signals from bathroom data, this area has received little to no attention. Wearables like Whoop and Oura needed to convince users that tracking HRV and sleep was important, but Throne doesn&#8217;t face that hurdle. This is because its core users have less need for education and face immediate health concerns. Patients with IBD, IBS, and prostate issues already understand the importance of monitoring symptoms, yet lack easy methods beyond memory, spreadsheets, or guesswork. Throne&#8217;s passive approach makes sustained long-term behavior change feasible. Over time, it reveals how factors like sleep, alcohol, medication, stress, and diet shape personal patterns, transforming passive data into actionable insights. This potential creates billions in enterprise value but isn&#8217;t the ultimate swing.</span></p><p><span>As Throne develops colon cancer screening features, its audience grows significantly, unlocking a new dimension of value&#8212;an extension many other consumer health devices are racing to build. Colon cancer is among the fastest-growing cancers in the U.S., increasingly affecting those under 50 and steering market interest toward early detection. While Cologuard, as the market leader, generates over $2 billion annually with a binary test, Throne aims to address an earlier need: helping individuals proactively understand how to prevent cancer before testing becomes necessary. Colon cancer is often preventable and highly treatable if caught early. If Throne can passively detect clinical signals without requiring behavioral changes, it will give larger diagnostic companies a strategic reason to view it as a frontline tool in cancer prevention, ultimately saving lives.</span></p><p>We are excited to back the incredible people, mission, and vision at <a href="https://thronescience.com/">Throne</a>!</p>

Strong conviction in world-class founders building a multi-billion-dollar consumer play around gut health and cancer detection.

Why We Invested in Somnee

Why We Invested in Somnee

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