<h3>What Is Throne?</h3><p>A passive, continuous health monitor embedded in your toilet seat turns a daily routine into valuable insights for gut health, hydration, and cancer detection. Throne is available today for stool and urine analysis and is designed as the &#8220;Whoop for Your Poop&#8221; for the 75 million Americans dealing with IBS, IBD, and prostate issues. The future version of Throne, known as the &#8220;Smoke Detector for Colon Cancer,&#8221; will expand its capabilities to include screening for one of the fastest-growing cancers in the United States.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!3IZ6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 424w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 848w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg" width="1200" height="630" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:630,&quot;width&quot;:1200,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:39385,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/208868655?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 424w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 848w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg aria-hidden="true" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><div><hr></div><p><span>Deciding to invest in a company usually hinges on two questions: 1) Will the founders find a way to succeed? 2) Is the target market large enough?</span></p><h3><span>Founder Bet</span></h3><p><a href="https://www.linkedin.com/in/scotthickle/"><span>Scott Hickle</span></a><span> is a founder who combines three qualities rarely found together: being a talent magnet, an obsession with solving the problem, and deep industry k</span><span data-color="#032b31" style="color: rgb(3, 43, 49);">nowledge. His motivation is straightforward &#8212; he&#8217;s passionate about saving lives and wants the Throne device on every accessible toilet. If you don&#8217;t believe us&#8230; His social handle is &#8220;</span><a href="https://x.com/ScottHickle"><span data-color="#032b31" style="color: rgb(3, 43, 49);">Poop Guy</span></a><span data-color="#032b31" style="color: rgb(3, 43, 49);">,&#8221; and he gave a </span><a href="https://www.youtube.com/watch?v=v42gznW6cuA"><span data-color="#032b31" style="color: rgb(3, 43, 49);">TED Talk </span></a><span data-color="#032b31" style="color: rgb(3, 43, 49);">on the history and significance of poop.</span></p><p><span data-color="#032b31" style="color: rgb(3, 43, 49);">Chasing an introduction to Throne kicked off an organic 18-month relationship before a check was written. We introduced him to multiple investo</span><span>rs who then joined this round, connected him with enterprise customers who remain engaged, and brought him before clinicians who initially questioned but ultimately left as believers in his right to win. Scott exemplifies a founder willing to bend reality with passionate intensity to make his business succeed.</span></p><p><span>His effectiveness is evident in the people he&#8217;s assembled. Scott recruited John Capodilupo, co-founder of Whoop and a key technical figure behind the $10B consumer health startup, who personally relates to the problem&#8212;living with ulcerative colitis. Scott also persuaded Ben Grynol, who previously led consumer growth at Levels, to join Throne. Scott established a medical advisory board with Dr. David Rubin and Dr. Mark Pimentel, renowned researchers with over 10,000 combined citations in IBS/IBD. Scott attracted an investor syndicate such as Emerson Collective, Will Ventures, Moxxie Ventures, Felix Capital, and Accomplice (an early supporter of Whoop).</span></p><h3><span>Market Bet</span></h3><p><span>In consumer health technology, continuous tracking now covers sleep, heart rate, glucose, and hormones, providing daily insights into bodily functions that influence habits. Despite valuable clinical signals from bathroom data, this area has received little to no attention. Wearables like Whoop and Oura needed to convince users that tracking HRV and sleep was important, but Throne doesn&#8217;t face that hurdle. This is because its core users have less need for education and face immediate health concerns. Patients with IBD, IBS, and prostate issues already understand the importance of monitoring symptoms, yet lack easy methods beyond memory, spreadsheets, or guesswork. Throne&#8217;s passive approach makes sustained long-term behavior change feasible. Over time, it reveals how factors like sleep, alcohol, medication, stress, and diet shape personal patterns, transforming passive data into actionable insights. This potential creates billions in enterprise value but isn&#8217;t the ultimate swing.</span></p><p><span>As Throne develops colon cancer screening features, its audience grows significantly, unlocking a new dimension of value&#8212;an extension many other consumer health devices are racing to build. Colon cancer is among the fastest-growing cancers in the U.S., increasingly affecting those under 50 and steering market interest toward early detection. While Cologuard, as the market leader, generates over $2 billion annually with a binary test, Throne aims to address an earlier need: helping individuals proactively understand how to prevent cancer before testing becomes necessary. Colon cancer is often preventable and highly treatable if caught early. If Throne can passively detect clinical signals without requiring behavioral changes, it will give larger diagnostic companies a strategic reason to view it as a frontline tool in cancer prevention, ultimately saving lives.</span></p><p>We are excited to back the incredible people, mission, and vision at <a href="https://thronescience.com/">Throne</a>!</p>

Strong conviction in world-class founders building a multi-billion-dollar consumer play around gut health and cancer detection.

Why We Backed Throne? A Bathroom Biomarker

Club Fútbol Estrela Amadora | Lisbon, Portugal | August 25, 2026

LEAD’s First-Ever Sports Team Ownership

<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!c8dD!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!c8dD!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!c8dD!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!c8dD!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!c8dD!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!c8dD!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png" width="1456" height="968" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:968,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:7250075,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/169752009?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!c8dD!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!c8dD!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!c8dD!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!c8dD!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F3bfc9efa-4d13-4997-93f7-8cc5c3072bd0_2875x1912.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><div class="pencraft pc-reset icon-container restack-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-refresh-cw"><path d="M3 12a9 9 0 0 1 9-9 9.75 9.75 0 0 1 6.74 2.74L21 8"></path><path d="M21 3v5h-5"></path><path d="M21 12a9 9 0 0 1-9 9 9.75 9.75 0 0 1-6.74-2.74L3 16"></path><path d="M8 16H3v5"></path></svg></div><div class="pencraft pc-reset icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></div></div></div></div></a></figure></div><p>Over the past 40 years, media innovation has largely focused on what we see. What we <em>hear</em>&#8212;and how we experience it&#8212;has barely evolved. Despite being an $82B market, audio has lagged far behind visual technology in innovation. For every dollar invested in visual tech, audio has received only a fraction, and patents in audio have grown at less than half the rate of those in imaging.</p><p><a href="https://www.edgesoundresearch.com/">EDGE Sound Research</a> is rewriting that script.</p><blockquote><p>&#8221;Our rationale for this investment centers on the market's recognition that the way humans &#8216;hear&#8217; (audio) has lacked innovation over the past forty years, especially when compared to advancements in the way humans &#8216;see&#8217; (media). Our enthusiasm for this investment stems from the solution's potential to address specific pain points across multiple industries, including sports, entertainment, automotive, and robotics.&#8221; - Justin Driscoll, Principal @ LEAD</p></blockquote><p><strong>Why Sound is the Next Frontier</strong></p><p>Audio limitations already constrain emerging tech&#8212;think VR headsets that deliver stunning visuals but rely on flat, two-dimensional soundscapes that break immersion. With over 20 million VR/AR headsets sold globally in 2024, the <a href="https://www.instagram.com/p/C8dWKCZA-Uw/">lack of spatially intelligent audio is a glaring gap</a> - overcoming it is key to fully realizing these experiences.</p><ul><li><p><strong>Immersive Tech Gap:</strong> VR/AR adoption is skyrocketing, yet spatial audio lags behind.</p></li><li><p><strong>Market Growth:</strong> The audio market is projected to triple to $275B by 2032.</p></li></ul><p>EDGE&#8217;s platform&#8212;spanning capture, processing, rendering, and reproduction&#8212;is creating a new category: <strong>intelligent audio.</strong></p><p>This isn&#8217;t just about louder or clearer sound. It&#8217;s about enabling computers to <em>understand</em> and <em>reproduce</em> sound in ways that feel human in immersive live sports, personalized broadcasts, and eventually, machines that hear and react like we do.</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Subscribe to receive the latest LEAD posts.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><p><strong>The Founders Who Hear Differently</strong></p><p>EDGE was born from two deeply personal journeys:</p><ul><li><p><strong><a href="https://www.linkedin.com/in/valsalomaki/">Valtteri Salomaki</a> (CEO):</strong> A serial entrepreneur with a knack for B2B sales in sports and entertainment</p></li><li><p><strong><a href="https://www.linkedin.com/in/ethancastro/">Ethan Castro</a> (CTO):</strong> Born hard of hearing, Ethan became a professional musician by training himself to <em>feel</em> sound.</p></li></ul><p>Together, they bridge technical brilliance and commercial execution&#8212;turning what was once academic research into real-world deployments.</p><p><strong>Why We Backed EDGE</strong></p><p>Fan feedback from early <a href="https://www.instagram.com/p/DMBo5kto0jo/">NBA arena deployments</a> showed a double-digit increase in reported engagement and immersion compared to traditional seating, underscoring the demand for this technology. Revenue tied to these installations has also grown steadily, reinforcing the commercial opportunity.</p><p>Our conviction rests on three pillars:</p><ol><li><p><strong>Category Creation:</strong> A first-of-its-kind intelligent audio stack with applications across live events, broadcast, automotive, and robotics.</p></li><li><p><strong>Real-World Traction:</strong> Deployments with the Cleveland Cavaliers, Fox Sports, and MLS validate demand.</p></li><li><p><strong>Platform Potential:</strong> From immersive fan experiences to teaching robots to hear, EDGE is building infrastructure for the next decade of sound.</p></li></ol><p><strong>What&#8217;s Next</strong></p><p>By this time next year, EDGE expects to double its number of venue installations and broadcast integrations, aligning with the broader convergence of AI in broadcast and robotics adoption.</p><p>With a $2.5M seed extension anchored by strategic partners like Sweetwater, EDGE is scaling Embodied Sound installations, commercializing its Virtual Sound Engine for broadcast, and exploring robotics integrations.</p><p>The <a href="https://www.instagram.com/p/C1tDruvLnsv/">future of audio</a> won&#8217;t just be heard&#8212;it will be <em>felt,</em> <em>personalized,</em> and ultimately <em>understood.</em> We&#8217;re thrilled to back EDGE as they make intelligent sound infrastructure a reality.</p><p>Edge Sound Research has <a href="https://www.sportsbusinessjournal.com/Articles/2025/06/27/usta-ventures-invests-in-edge-sound-research/">raised $2.75M in new funding</a>, bringing the audio innovation startup&#8217;s total backing to $5.5M. The latest round was led by Elevate Ventures and included participation from USTA Ventures, the DeVos family, LEAD VC, Cartan Capital, and Potential Capital, among other angel investors in the audio and entertainment space.</p><p><em>Disclosure: EDGE Sound Research participated in the inaugural <a href="https://www.sportsbusinessjournal.com/Articles/2025/04/18/magic-select-five-companies-in-inaugural-magic-venture-challenge/">Orlando Magic Venture Challenge</a>.</em></p><div class="captioned-button-wrap" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/why-we-invested-in-edge-sound-research?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="CaptionedButtonToDOM"><div class="preamble"><p class="cta-caption">Thanks for reading! Feel feel free to share it with someone who it resonates with.</p></div><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/why-we-invested-in-edge-sound-research?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://leadvc.substack.com/p/why-we-invested-in-edge-sound-research?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p></div>

Reinventing audio for an immersive, AI-driven future.

Why We Invested in Edge Sound Research

<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!7koX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" width="1456" height="968" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:968,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:6605001,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p>When the topic of chronic diseases is discussed in the United States, an increasing amount of attention has been directed, and rightfully so, toward clean ingredients in our food supply and getting adequate exercise. However, not many people consider or monitor the quality of the physical spaces that hold our presence - environments where we live, work, and sleep.</p><p>As my mentor would say, &#8220;You cannot heal in the same environment where you got sick.&#8221;</p><p>Just like food, your home is medicine too.</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Thanks for reading! Subscribe now to receive LEAD&#8217;s latest posts.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><p><strong>The Overlooked Factor: Where We Spend 90% of Our Lives</strong></p><p>We spend <a href="https://www.epa.gov/indoor-air-quality-iaq/improving-your-indoor-environment">90%</a> of our time indoors, and the current medical literature recognizes that <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4841276/">70% to 90%</a> of disease risks may be <a href="https://www.sciencedirect.com/science/article/pii/S2666979X24001757">due</a> to environmental differences.</p><p>A health-conscious individual could get 100+ blood tests every 6 months and keep adding to the supplement stack, but if the underlying environmental factors contributing to the symptoms, such as chronic mold or PFAS exposure, are not addressed, at what point is the current wellness industry (a <a href="https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/the-trends-defining-the-1-point-8-trillion-dollar-global-wellness-market-in-2024">$1.8T market</a>) simply putting band-aids over problems without ever addressing the underlying causes, all the while draining people&#8217;s wallets?</p><p><strong>The Unseen Disease-Causing Substances in Our Homes</strong></p><p>It is estimated that approximately <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10190119/">47%</a> of residential buildings show signs of mold, and that chronic indoor damp/mold-contaminated air exposure can <a href="https://pubmed.ncbi.nlm.nih.gov/32078193/">contribute</a> to low-grade pro-inflammatory responses and damage human airways. Evidence suggests that building dampness and mold are associated with a <a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0668.2007.00475.x">30-50%</a> increase in a variety of respiratory and asthma-related health outcomes.</p><p>And chronic mold exposure is just the tip of the iceberg.</p><p><strong>Flame Retardants</strong></p><p>Applied to prevent or slow the growth of fire, these chemicals are found in couches, mattresses, carpets, and building materials.</p><p>Flame retardants are <a href="https://pubmed.ncbi.nlm.nih.gov/21268442/">associated with adverse health effects</a> such as endocrine and thyroid disruption, immunotoxicity, reproductive toxicity, and cancer. </p><p><em>Imagine sleeping on these chemicals for approximately 1/3 of our lives.</em></p><p><strong>Phthalates</strong></p><p>Widely found in personal care products, scented products, and plastic coatings, phthalates are known <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8157593/">endocrine disruptors</a> and can have detrimental impacts on the human reproductive, neurological, and developmental systems.</p><p><strong>Volatile Organic Compounds</strong></p><p>VOCs are found in a wide range of everyday products and materials such as paints, adhesives, carpets, beauty products, and cleaning products. These chemicals cause oxidative stress, inflammation, and <a href="https://pubmed.ncbi.nlm.nih.gov/38320440/">elevated lung cancer risk</a>. </p><p>The level of VOCs can also be <a href="https://pubmed.ncbi.nlm.nih.gov/27163962/">higher</a> indoors than outdoors, with some compounds reaching levels <a href="https://www.epa.gov/indoor-air-quality-iaq/volatile-organic-compounds-impact-indoor-air-quality">two to five times</a> higher inside homes.</p><p><strong>PFAS (&#8221;Forever Chemicals&#8221;)</strong></p><p>Per- and polyfluroalkyl substances are <a href="https://ncpure.collaboratory.unc.edu/science/where-are-pfas-found/">everywhere</a>, from personal care products and food packagings, to non-stick cookwares and water-repellent chemicals used on upholstery. The USGS estimates that at least <a href="https://www.usgs.gov/news/national-news-release/tap-water-study-detects-pfas-forever-chemicals-across-us">45%</a> of tap water in the U.S. has one or more types of PFAS.</p><p>Studies have revealed associations between specific PFAS exposure with <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">negative health effects</a> such as altered immune and thyroid function, liver disease, insulin dysregulation, kidney disease, adverse reproductive outcomes, and cancer. What&#8217;s more concerning is that these substances <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">bind to proteins</a> and accumulate in the body.</p><p>PFAS can also <a href="https://www.sciencedirect.com/science/article/pii/S0160412024003581">permeate the skin barrier</a> and reach the body&#8217;s bloodstream, making dermal exposure another route of adding to the accumulated burden of PFAS.</p><p><strong>Man-made Electromagnetic Radiation (EMR)</strong></p><p>Man-made EMR, in contrast to natural EMR, are <a href="https://www.nature.com/articles/srep14914">polarized</a>, and the <a href="https://www.nature.com/articles/srep14914">health effects include</a> DNA and protein damage, which may result in cell death, reproductive declines, and cancer.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!CpuG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" width="1280" height="720" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:720,&quot;width&quot;:1280,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:230182,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p><strong>The Opportunity:</strong></p><p>From 2017-2023, more than <a href="https://www.census.gov/library/stories/2025/01/return-home-migration.html">40 million people</a> moved in the United States, and the average person in the U.S. can expect to relocate <a href="https://www.census.gov/topics/population/migration/guidance/calculating-migration-expectancy.html#:~:text=Using%202007%20ACS%20data%2C%20it%20is%20estimated,expected%20number%20of%20moves%20is%20only%202.7.)">11.7 times</a> in their lifetime.</p><p>What if every time someone moves, they could order a test kit to make sure that the new environment is supportive of health? What if in humid environments, people could check the health of their homes every six months?</p><p>What if one platform could test for:</p><ul><li><p>Lighting</p></li><li><p>EMF</p></li><li><p>Water quality</p></li><li><p>Air quality</p></li><li><p>Mold</p></li><li><p>Chemical hazards</p></li></ul><p>&#8230;and then instantly connect consumers with home specialists and solutions to address the issues found, rather than providing only pharmaceutical treatments or supplements?</p><p>If you are an innovator, builder, or passionate about solving these challenges, reach out to me on <a href="https://www.linkedin.com/in/kaiwenliu6/">LinkedIn</a> or connect with us at <a href="mailto:dealflow@lead.vc">dealflow@lead.vc</a>.</p><div class="captioned-button-wrap" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="CaptionedButtonToDOM"><div class="preamble"><p class="cta-caption">Thanks for reading! Feel free to share it!</p></div><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p></div>

The overlooked aspect of health and wellness.

Why We Backed Throne? A Bathroom Biomarker

Why We Backed Throne? A Bathroom Biomarker

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