<h3>What Is Throne?</h3><p>A passive, continuous health monitor embedded in your toilet seat turns a daily routine into valuable insights for gut health, hydration, and cancer detection. Throne is available today for stool and urine analysis and is designed as the &#8220;Whoop for Your Poop&#8221; for the 75 million Americans dealing with IBS, IBD, and prostate issues. The future version of Throne, known as the &#8220;Smoke Detector for Colon Cancer,&#8221; will expand its capabilities to include screening for one of the fastest-growing cancers in the United States.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!3IZ6!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 424w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 848w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg" width="1200" height="630" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:630,&quot;width&quot;:1200,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:39385,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/208868655?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!3IZ6!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 424w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 848w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!3IZ6!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe6317f8f-6ae9-4516-ba0b-660001df7160_1200x630.jpeg 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg aria-hidden="true" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><div><hr></div><p><span>Deciding to invest in a company usually hinges on two questions: 1) Will the founders find a way to succeed? 2) Is the target market large enough?</span></p><h3><span>Founder Bet</span></h3><p><a href="https://www.linkedin.com/in/scotthickle/"><span>Scott Hickle</span></a><span> is a founder who combines three qualities rarely found together: being a talent magnet, an obsession with solving the problem, and deep industry k</span><span data-color="#032b31" style="color: rgb(3, 43, 49);">nowledge. His motivation is straightforward &#8212; he&#8217;s passionate about saving lives and wants the Throne device on every accessible toilet. If you don&#8217;t believe us&#8230; His social handle is &#8220;</span><a href="https://x.com/ScottHickle"><span data-color="#032b31" style="color: rgb(3, 43, 49);">Poop Guy</span></a><span data-color="#032b31" style="color: rgb(3, 43, 49);">,&#8221; and he gave a </span><a href="https://www.youtube.com/watch?v=v42gznW6cuA"><span data-color="#032b31" style="color: rgb(3, 43, 49);">TED Talk </span></a><span data-color="#032b31" style="color: rgb(3, 43, 49);">on the history and significance of poop.</span></p><p><span data-color="#032b31" style="color: rgb(3, 43, 49);">Chasing an introduction to Throne kicked off an organic 18-month relationship before a check was written. We introduced him to multiple investo</span><span>rs who then joined this round, connected him with enterprise customers who remain engaged, and brought him before clinicians who initially questioned but ultimately left as believers in his right to win. Scott exemplifies a founder willing to bend reality with passionate intensity to make his business succeed.</span></p><p><span>His effectiveness is evident in the people he&#8217;s assembled. Scott recruited John Capodilupo, co-founder of Whoop and a key technical figure behind the $10B consumer health startup, who personally relates to the problem&#8212;living with ulcerative colitis. Scott also persuaded Ben Grynol, who previously led consumer growth at Levels, to join Throne. Scott established a medical advisory board with Dr. David Rubin and Dr. Mark Pimentel, renowned researchers with over 10,000 combined citations in IBS/IBD. Scott attracted an investor syndicate such as Emerson Collective, Will Ventures, Moxxie Ventures, Felix Capital, and Accomplice (an early supporter of Whoop).</span></p><h3><span>Market Bet</span></h3><p><span>In consumer health technology, continuous tracking now covers sleep, heart rate, glucose, and hormones, providing daily insights into bodily functions that influence habits. Despite valuable clinical signals from bathroom data, this area has received little to no attention. Wearables like Whoop and Oura needed to convince users that tracking HRV and sleep was important, but Throne doesn&#8217;t face that hurdle. This is because its core users have less need for education and face immediate health concerns. Patients with IBD, IBS, and prostate issues already understand the importance of monitoring symptoms, yet lack easy methods beyond memory, spreadsheets, or guesswork. Throne&#8217;s passive approach makes sustained long-term behavior change feasible. Over time, it reveals how factors like sleep, alcohol, medication, stress, and diet shape personal patterns, transforming passive data into actionable insights. This potential creates billions in enterprise value but isn&#8217;t the ultimate swing.</span></p><p><span>As Throne develops colon cancer screening features, its audience grows significantly, unlocking a new dimension of value&#8212;an extension many other consumer health devices are racing to build. Colon cancer is among the fastest-growing cancers in the U.S., increasingly affecting those under 50 and steering market interest toward early detection. While Cologuard, as the market leader, generates over $2 billion annually with a binary test, Throne aims to address an earlier need: helping individuals proactively understand how to prevent cancer before testing becomes necessary. Colon cancer is often preventable and highly treatable if caught early. If Throne can passively detect clinical signals without requiring behavioral changes, it will give larger diagnostic companies a strategic reason to view it as a frontline tool in cancer prevention, ultimately saving lives.</span></p><p>We are excited to back the incredible people, mission, and vision at <a href="https://thronescience.com/">Throne</a>!</p>

Strong conviction in world-class founders building a multi-billion-dollar consumer play around gut health and cancer detection.

Why We Backed Throne? A Bathroom Biomarker

<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!7koX!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png" width="1456" height="968" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:968,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:6605001,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!7koX!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 424w, https://substackcdn.com/image/fetch/$s_!7koX!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 848w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1272w, https://substackcdn.com/image/fetch/$s_!7koX!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2F4224403d-405f-4a8d-a738-9065401105e5_2875x1912.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p>When the topic of chronic diseases is discussed in the United States, an increasing amount of attention has been directed, and rightfully so, toward clean ingredients in our food supply and getting adequate exercise. However, not many people consider or monitor the quality of the physical spaces that hold our presence - environments where we live, work, and sleep.</p><p>As my mentor would say, &#8220;You cannot heal in the same environment where you got sick.&#8221;</p><p>Just like food, your home is medicine too.</p><div class="subscription-widget-wrap-editor" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/subscribe?&quot;,&quot;text&quot;:&quot;Subscribe&quot;,&quot;language&quot;:&quot;en&quot;}" data-component-name="SubscribeWidgetToDOM"><div class="subscription-widget show-subscribe"><div class="preamble"><p class="cta-caption">Thanks for reading! Subscribe now to receive LEAD&#8217;s latest posts.</p></div><form class="subscription-widget-subscribe"><input type="email" class="email-input" name="email" placeholder="Type your email&#8230;" tabindex="-1"><input type="submit" class="button primary" value="Subscribe"><div class="fake-input-wrapper"><div class="fake-input"></div><div class="fake-button"></div></div></form></div></div><p><strong>The Overlooked Factor: Where We Spend 90% of Our Lives</strong></p><p>We spend <a href="https://www.epa.gov/indoor-air-quality-iaq/improving-your-indoor-environment">90%</a> of our time indoors, and the current medical literature recognizes that <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC4841276/">70% to 90%</a> of disease risks may be <a href="https://www.sciencedirect.com/science/article/pii/S2666979X24001757">due</a> to environmental differences.</p><p>A health-conscious individual could get 100+ blood tests every 6 months and keep adding to the supplement stack, but if the underlying environmental factors contributing to the symptoms, such as chronic mold or PFAS exposure, are not addressed, at what point is the current wellness industry (a <a href="https://www.mckinsey.com/industries/consumer-packaged-goods/our-insights/the-trends-defining-the-1-point-8-trillion-dollar-global-wellness-market-in-2024">$1.8T market</a>) simply putting band-aids over problems without ever addressing the underlying causes, all the while draining people&#8217;s wallets?</p><p><strong>The Unseen Disease-Causing Substances in Our Homes</strong></p><p>It is estimated that approximately <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC10190119/">47%</a> of residential buildings show signs of mold, and that chronic indoor damp/mold-contaminated air exposure can <a href="https://pubmed.ncbi.nlm.nih.gov/32078193/">contribute</a> to low-grade pro-inflammatory responses and damage human airways. Evidence suggests that building dampness and mold are associated with a <a href="https://onlinelibrary.wiley.com/doi/10.1111/j.1600-0668.2007.00475.x">30-50%</a> increase in a variety of respiratory and asthma-related health outcomes.</p><p>And chronic mold exposure is just the tip of the iceberg.</p><p><strong>Flame Retardants</strong></p><p>Applied to prevent or slow the growth of fire, these chemicals are found in couches, mattresses, carpets, and building materials.</p><p>Flame retardants are <a href="https://pubmed.ncbi.nlm.nih.gov/21268442/">associated with adverse health effects</a> such as endocrine and thyroid disruption, immunotoxicity, reproductive toxicity, and cancer. </p><p><em>Imagine sleeping on these chemicals for approximately 1/3 of our lives.</em></p><p><strong>Phthalates</strong></p><p>Widely found in personal care products, scented products, and plastic coatings, phthalates are known <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC8157593/">endocrine disruptors</a> and can have detrimental impacts on the human reproductive, neurological, and developmental systems.</p><p><strong>Volatile Organic Compounds</strong></p><p>VOCs are found in a wide range of everyday products and materials such as paints, adhesives, carpets, beauty products, and cleaning products. These chemicals cause oxidative stress, inflammation, and <a href="https://pubmed.ncbi.nlm.nih.gov/38320440/">elevated lung cancer risk</a>. </p><p>The level of VOCs can also be <a href="https://pubmed.ncbi.nlm.nih.gov/27163962/">higher</a> indoors than outdoors, with some compounds reaching levels <a href="https://www.epa.gov/indoor-air-quality-iaq/volatile-organic-compounds-impact-indoor-air-quality">two to five times</a> higher inside homes.</p><p><strong>PFAS (&#8221;Forever Chemicals&#8221;)</strong></p><p>Per- and polyfluroalkyl substances are <a href="https://ncpure.collaboratory.unc.edu/science/where-are-pfas-found/">everywhere</a>, from personal care products and food packagings, to non-stick cookwares and water-repellent chemicals used on upholstery. The USGS estimates that at least <a href="https://www.usgs.gov/news/national-news-release/tap-water-study-detects-pfas-forever-chemicals-across-us">45%</a> of tap water in the U.S. has one or more types of PFAS.</p><p>Studies have revealed associations between specific PFAS exposure with <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">negative health effects</a> such as altered immune and thyroid function, liver disease, insulin dysregulation, kidney disease, adverse reproductive outcomes, and cancer. What&#8217;s more concerning is that these substances <a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC7906952/">bind to proteins</a> and accumulate in the body.</p><p>PFAS can also <a href="https://www.sciencedirect.com/science/article/pii/S0160412024003581">permeate the skin barrier</a> and reach the body&#8217;s bloodstream, making dermal exposure another route of adding to the accumulated burden of PFAS.</p><p><strong>Man-made Electromagnetic Radiation (EMR)</strong></p><p>Man-made EMR, in contrast to natural EMR, are <a href="https://www.nature.com/articles/srep14914">polarized</a>, and the <a href="https://www.nature.com/articles/srep14914">health effects include</a> DNA and protein damage, which may result in cell death, reproductive declines, and cancer.</p><div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!CpuG!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg" width="1280" height="720" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/e8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:720,&quot;width&quot;:1280,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:230182,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/jpeg&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:true,&quot;topImage&quot;:false,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/168960959?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!CpuG!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 424w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 848w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1272w, https://substackcdn.com/image/fetch/$s_!CpuG!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fe8fd321f-bbb4-4f9c-b786-183578e913dd_1280x720.jpeg 1456w" sizes="100vw" loading="lazy"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" style="height:20px;width:20px" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p><strong>The Opportunity:</strong></p><p>From 2017-2023, more than <a href="https://www.census.gov/library/stories/2025/01/return-home-migration.html">40 million people</a> moved in the United States, and the average person in the U.S. can expect to relocate <a href="https://www.census.gov/topics/population/migration/guidance/calculating-migration-expectancy.html#:~:text=Using%202007%20ACS%20data%2C%20it%20is%20estimated,expected%20number%20of%20moves%20is%20only%202.7.)">11.7 times</a> in their lifetime.</p><p>What if every time someone moves, they could order a test kit to make sure that the new environment is supportive of health? What if in humid environments, people could check the health of their homes every six months?</p><p>What if one platform could test for:</p><ul><li><p>Lighting</p></li><li><p>EMF</p></li><li><p>Water quality</p></li><li><p>Air quality</p></li><li><p>Mold</p></li><li><p>Chemical hazards</p></li></ul><p>&#8230;and then instantly connect consumers with home specialists and solutions to address the issues found, rather than providing only pharmaceutical treatments or supplements?</p><p>If you are an innovator, builder, or passionate about solving these challenges, reach out to me on <a href="https://www.linkedin.com/in/kaiwenliu6/">LinkedIn</a> or connect with us at <a href="mailto:dealflow@lead.vc">dealflow@lead.vc</a>.</p><div class="captioned-button-wrap" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="CaptionedButtonToDOM"><div class="preamble"><p class="cta-caption">Thanks for reading! Feel free to share it!</p></div><p class="button-wrapper" data-attrs="{&quot;url&quot;:&quot;https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share&quot;,&quot;text&quot;:&quot;Share&quot;}" data-component-name="ButtonCreateButton"><a class="button primary" href="https://leadvc.substack.com/p/home-as-medicine?utm_source=substack&utm_medium=email&utm_content=share&action=share"><span>Share</span></a></p></div>

The overlooked aspect of health and wellness.

Home as Medicine

Comics Is Exploding, and GlobalComix Is Building the Platform for It

Why We Invested in GlobalComix

<div class="captioned-image-container"><figure><a class="image-link image2 is-viewable-img" target="_blank" href="https://substackcdn.com/image/fetch/$s_!9TCH!,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png" data-component-name="Image2ToDOM"><div class="image2-inset"><picture><source type="image/webp" srcset="https://substackcdn.com/image/fetch/$s_!9TCH!,w_424,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 424w, https://substackcdn.com/image/fetch/$s_!9TCH!,w_848,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 848w, https://substackcdn.com/image/fetch/$s_!9TCH!,w_1272,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 1272w, https://substackcdn.com/image/fetch/$s_!9TCH!,w_1456,c_limit,f_webp,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 1456w" sizes="100vw"><img src="https://substackcdn.com/image/fetch/$s_!9TCH!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png" width="1456" height="817" data-attrs="{&quot;src&quot;:&quot;https://substack-post-media.s3.amazonaws.com/public/images/b893b23e-bee8-4e54-8ac2-474173538420_1742x978.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;fullscreen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:817,&quot;width&quot;:1456,&quot;resizeWidth&quot;:null,&quot;bytes&quot;:1337300,&quot;alt&quot;:null,&quot;title&quot;:null,&quot;type&quot;:&quot;image/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topImage&quot;:true,&quot;internalRedirect&quot;:&quot;https://leadvc.substack.com/i/201233039?img=https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png&quot;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:false}" class="sizing-normal" alt="" srcset="https://substackcdn.com/image/fetch/$s_!9TCH!,w_424,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 424w, https://substackcdn.com/image/fetch/$s_!9TCH!,w_848,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 848w, https://substackcdn.com/image/fetch/$s_!9TCH!,w_1272,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 1272w, https://substackcdn.com/image/fetch/$s_!9TCH!,w_1456,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%2Fpublic%2Fimages%2Fb893b23e-bee8-4e54-8ac2-474173538420_1742x978.png 1456w" sizes="100vw" fetchpriority="high"></picture><div class="image-link-expand"><div class="pencraft pc-display-flex pc-gap-8 pc-reset"><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container restack-image"><svg role="img" width="20" height="20" viewBox="0 0 20 20" fill="none" stroke-width="1.5" stroke="var(--color-fg-primary)" stroke-linecap="round" stroke-linejoin="round" xmlns="http://www.w3.org/2000/svg"><g><title></title><path d="M2.53001 7.81595C3.49179 4.73911 6.43281 2.5 9.91173 2.5C13.1684 2.5 15.9537 4.46214 17.0852 7.23684L17.6179 8.67647M17.6179 8.67647L18.5002 4.26471M17.6179 8.67647L13.6473 6.91176M17.4995 12.1841C16.5378 15.2609 13.5967 17.5 10.1178 17.5C6.86118 17.5 4.07589 15.5379 2.94432 12.7632L2.41165 11.3235M2.41165 11.3235L1.5293 15.7353M2.41165 11.3235L6.38224 13.0882"></path></g></svg></button><button tabindex="0" type="button" class="pencraft pc-reset pencraft icon-container view-image"><svg xmlns="http://www.w3.org/2000/svg" width="20" height="20" viewBox="0 0 24 24" fill="none" stroke="currentColor" stroke-width="2" stroke-linecap="round" stroke-linejoin="round" class="lucide lucide-maximize2 lucide-maximize-2"><polyline points="15 3 21 3 21 9"></polyline><polyline points="9 21 3 21 3 15"></polyline><line x1="21" x2="14" y1="3" y2="10"></line><line x1="3" x2="10" y1="21" y2="14"></line></svg></button></div></div></div></a></figure></div><p>There&#8217;s no denying that sports teams have some of the most loyal customer bases in the world. Yet despite valuations in the billions, most teams don&#8217;t know their fans&#8217; names (or much else about them) because they don&#8217;t own their consumer data. That gap, in our eyes, is the structural problem in sports &#8212; they are not acting like consumer brands. </p><p>The critique isn&#8217;t that valuations are wrong, but that they are incomplete. Today&#8217;s market prices in brand equity and media rights, but not yet data infrastructure or the compounding value of a direct customer relationship built over decades. The conventional justification is that the supply of sports teams is scarce, fans don&#8217;t churn, and a new investor will always want in. We don&#8217;t disagree. But it explains the floor, not the ceiling.</p><p>Data infrastructure and customer data don&#8217;t appear in a traditional sports team&#8217;s valuation, but they do in every other consumer business. Netflix commands its valuation not because of its content library alone, but because it knows exactly who is watching, when they stop, and what brings them back. That gap between what a sports team is worth today and what it could be if it centered on fan data is where the next tier of value is created.</p><div><hr></div><h4><strong>I. The Valuation Paradox</strong></h4><p>In the last 5 years, franchise valuations have defied gravity. The NFL&#8217;s average team now exceeds $5 billion, with the NBA, NHL, MLB, and European football clubs not far behind &#8212; all trading at multiples that compare to most tech deals. Every new sale seems to set a record that the next one breaks.</p><p>And to be fair, the track record justifies the attention. Over the past two decades, the big four North American leagues have generated 13.2% annualized returns (outpacing the S&amp;P 500 by more than 2x). As an asset class, sports franchises have been among the most consistent wealth-creation vehicles over the last generation.</p><p>When you look past the headlines, most teams still run a business model designed for a different era. They don&#8217;t own their ticketing infrastructure, don&#8217;t control their merchandise, and have outsourced their media rights. At some point, price appreciation alone stops being a thesis. We are confident that reality has either arrived or is close.</p><p>The business of sports teams is not easily explained on a spreadsheet. The real question is what they would be worth if they were run like a consumer brand that owned its customers?</p><div><hr></div><h4><strong>II. A Brand With No Customer</strong></h4><p>Think about the brands with the most loyal customers in the world: Apple, Netflix, Adidas, and Spotify. Their business is built around one obsession: knowing their customers better than anyone else. Spotify knows your favorite artist and can recommend a new song to you. Adidas knows which sneakers you bought and can offer a special-edition Samba next release. Now think about your favorite sports team. You've worn the jersey since you were 8 years old. You've never missed a home game, with season tickets, exclusive merchandise, and the league pass. Chances are, the team has no idea who you are.</p><p>Sports franchises sit on the most emotionally committed customer bases ever assembled. This is loyalty that consumer brands spend billions trying to manufacture. In sports, it exists organically and is inherited across generations, geographies, identities, and communities. By every metric that matters in a modern consumer business, teams have already won the hardest part. It&#8217;s precisely why sponsorship commands such a premium: partner brands are paying to access a loyal customer base they could never build on their own.</p><p>And yet, structurally, they operate like a business that is not direct-to-consumer.</p><p>The average fan can appear as four entirely different users across four entirely different systems. The ticketing platform knows you by your seat number. The merchandise provider knows you by your shipping address. The broadcast partner knows you by your subscriber ID. The team itself? Often, it knows you as little more than an email address. Of course, through innovation, this is changing drastically, and it is most teams&#8217; top priority.<br><br>The average fan can appear as four different users across four entirely different systems. The ticketing platform knows you by your seat number; the merchandise provider by your shipping address; the broadcast partner by your subscriber ID. The team itself? Often, little more than an email address. Through innovation, this is changing drastically, and it is most teams&#8217; top priority.</p><p>The model currently optimizes for the vendor partner over the fan relationship. It has not measured what it&#8217;s losing: the compounding value of unified fan data.</p><div><hr></div><h4><strong>III. Why Intermediaries Made Sense And Why They Don&#8217;t Anymore</strong></h4><p>For most of the 20th century, sports organizations lacked the technology and operational infrastructure to sell directly to fans at scale. Ticketmaster could distribute inventory across thousands of outlets. Fanatics could manufacture, warehouse, and ship merchandise globally. Broadcast networks could reach tens of millions of households that no team could reach.</p><p>The problem isn&#8217;t that intermediaries exist. It&#8217;s what happens over time when the entire fan relationship is built on someone else&#8217;s infrastructure.</p><p>Every time a fan interaction is outsourced, the team loses a little more visibility into who that fan is, what they value, and how their behaviors connect. Intermediaries don&#8217;t just take margin; they take context. And unlike margin, context doesn&#8217;t show up on financials until it&#8217;s gone.</p><p>The model highlights a structural weakness: the idea that ticketing, merchandise, media, and sponsorship are separate businesses that happen to share a logo. Each vendor relationship became its own silo, with its own contract, data, and definition of who the customer is.</p><div><hr></div><h4><strong>IV. What Would a D2C Business Model Look Like?</strong></h4><p>We provide a blank-page exercise exploring what could be possible if they were run more like a consumer business, with examples below.</p><ul><li><p><em>Ticketing: </em>The status quo is that outsourced providers such as Ticketmaster, Live Nation, SeatGeek, StubHub, and others control primary/secondary distribution. The D2C vision is to sell inventory through owned channels, with price optimization and other strategies managed by the team.</p></li><li><p><em>Media/Broadcast: </em>The status quo is that broadcast rights deals are the dominant revenue engine for teams today. The D2C vision is to include behind-the-scenes programming, player storytelling, and other content opportunities owned by teams and leagues, built on a direct, owned audience.</p></li><li><p><em>Merchandise: </em>The status quo is that Fanatics controls manufacturing and distribution for most major North American league apparel. The D2C vision is to sell all merchandise through an owned commerce infrastructure, in which the sports team retains all customer data.</p></li></ul><div><hr></div><h4><strong>V. The Talent Evolution in Sports</strong></h4><p>If the problem were technological, it would already be solved. The tools to build a D2C business exist and are accessible; the harder problem is organizational.</p><p>For decades, the sports industry has been powered by career insiders, people who have built deep institutional knowledge over 20 years within the same organization, league, or ecosystem. That experience is genuinely irreplaceable. Nobody understands a fanbase, a market, or a league relationship better than someone who has lived inside it for a generation.</p><p>But the next chapter of value creation requires bringing in diverse thought and experience alongside these leaders. In technology, the pace of change is relentless by design. Companies like Anthropic, SpaceX, and Ramp operate on an iteration cadence that most industries never experience. Operators who have built consumer businesses from scratch think differently about data, retention, and customer lifetime value.</p><p>Sports are beginning to import talent. AC Milan hired Maxime Laharrague, formerly a data scientist and insights manager at Spotify, to lead their data strategy across business and marketing. The Florida Panthers brought in Michael White, President of Business Operations, who previously served as Chief Product Officer at Amazon&#8217;s autonomous vehicle division. These examples are early signals of what more ownership groups will begin to implement.<br><br>Sports are beginning to import talent. AC Milan hired Maxime Laharrague, a Spotify data scientist and insights manager, to lead their data strategy across business and marketing. The Florida Panthers brought in Michael White as President of Business Operations, a former Chief Product Officer at Amazon&#8217;s autonomous vehicle division. These are early signals of what more ownership groups will begin to implement.</p><div><hr></div><h4><strong>VI. The Valuation Implication </strong></h4><p>Here&#8217;s the question we keep coming back to: if two teams generate identical revenue but one runs through intermediaries and the other through owned channels with first-party data infrastructure, are they worth the same multiple? We don&#8217;t think so. Not even close.</p><p>When a team knows every fan, it can model churn, underwrite a fan product, build sponsorships based on verified performance, and personalize experiences at scale. It carries a technology asset alongside the sports asset. The comps stop being other sports teams and start looking more like Spotify and Netflix: consumer businesses where the depth of the customer relationship is itself a source of enterprise value.</p><p>That&#8217;s the shift we&#8217;re watching for at LEAD. Not which team sells next, or at what price, but which groups are quietly building the infrastructure that turns every fan relationship and data point into a driver of valuation.</p><p>The teams that get there first won&#8217;t just be worth more; they&#8217;ll be worth it.</p>

There's no denying that sports teams have the world's most loyal customers. Despite being worth billions, they still don't know everything about their fans.

Why We Backed Throne? A Bathroom Biomarker

Why We Backed Throne? A Bathroom Biomarker

sign up to our newsletter